HBT: Cubs would eat $26M on Soriano's contract

The Cubs ate a lot of Carlos Zambrano?s contract when he went to the Marlins just to be rid of him and they are willing to do the same thing with Alfonso Soriano, reports Jon Heyman: specifically, $26 million of the $36 million Soriano is owed over the next two seasons.

The catch: you gotta give the Cubs an actual prospect.

Which might be tempting for a lot of teams, depending on how good the prospect is. ?Soriano hit .262/.322/.499 with 32 home runs and 108 RBI in 151 games this past season for Chicago. And while he?s not likely to repeat those numbers again in 2013, some power and durability in left field or at DH for $5 million a year is quite a bargain these days.

Source: http://hardballtalk.nbcsports.com/2012/12/13/the-cubs-would-eat-26-million-of-the-36-million-owed-alfonso-soriano/related/

Jessica Ghawi

New biomarker for bone marrow cancer: Discovery suggests new ways of treating multiple myeloma

Dec. 12, 2012 ? Singapore scientists have identified FAIM, a molecule that typically prevents cell death, as a potential biomarker to identify an incurable form of cancer in the bone marrow. Patients with this form of cancer usually do not get cured with current standard treatments such as chemotherapy and stem cell transplantation, with an average survival of only about four years. FAIM could thus be a therapeutic target in these patients, as drugs developed to target the molecule could destroy multiple myeloma cells and hence eradicate the cancer.

Multiple myeloma is an incurable cancer of blood cells, which arises due to an uncontrollable accumulation of antibody-producing plasma cells in the bone marrow. In Singapore, about 80 new cases of multiple myeloma are diagnosed every year. Unfortunately, most people who develop multiple myeloma have no clearly identifiable risk factors for the disease but factors such as individuals older than 50 years of age, men and obesity, may predispose one to the cancer.

The scientists discovered that a protein called Fas apoptosis inhibitory molecule (FAIM) can affect the activation of Akt, an important enzyme required for cancer cell proliferation. By silencing the expression of FAIM, the team showed that the myeloma cells could be destroyed. It was also found that this protein was present at higher levels in the plasma cells of these patients as compared to normal individuals, and that higher levels of FAIM correlated to poorer survival outcomes of patients. This is an important breakthrough as it not only identifies FAIM as a useful biomarker of multiple myeloma patients, but also as a good target that drugs can be developed for, in order to get rid of the cancer cells.

This collaborative research was conducted by scientists at A*STAR's Bioprocessing Technology Institute (BTI) led by Prof Lam Kong-Peng, along with clinician-scientists at National University Cancer Institute, Singapore (NCIS) and the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore. The research findings were published in Leukemia on 5 December 2012.

Prof Lam said, "This study adds onto previous studies in the institute demonstrating the utility of FAIM not only in biotechnology but now potentially in the clinic. It is a prime example of how a better understanding of FAIM protein function enables us to first use it to increase yield in biologics manufacturing, and now as a potential prognostic biomarker in the clinic for a deadly human disease such as multiple myeloma. This is really a translation from bench-to-bioreactor and bench-to-bedside."

"Treatment failure due to drug resistance is an important reason why patients with multiple myeloma have a poor outcome. In this study, we identified FAIM as a new biomarker that is associated with poor outcome as well as an important mediator of growth signals in myeloma cells that could lead to drug resistance. The detection of this biomarker will allow us to identify these high risk patients and possibly develop treatments that target FAIM to improve their outcome. This study also underlines the potential for collaborative work between A*STAR research institutes (BTI), CSI Singapore and the National University Cancer Institute of Singapore (NCIS) to perform research that may have significant impact on patients," said Associate Professor Chng Wee Joo, who is Senior Consultant Haematologist at the Department of Haematology-Oncology, NCIS and Senior Principal Investigator at CSI.

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The above story is reprinted from materials provided by Agency for Science, Technology and Research (A*STAR), Singapore.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. J Huo, S Xu, B Lin, W-J Chng, K-P Lam. Fas apoptosis inhibitory molecule is upregulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in multiple myeloma. Leukemia, 2012; DOI: 10.1038/leu.2012.326

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/dvq6xHMll0k/121213104233.htm

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Leonardo DiCaprio, Anne Hathaway 'Honored' By Golden Globe Nods

Emily Blunt, Helen Mirren and Jessica Chastain also share how 'elated' they are to receive nominations from the Hollywood Foreign Press Association.
By Kara Warner

Leonardo DiCaprio in "Django Unchained"
Photo: Weinstein Company

Source: http://www.mtv.com/news/articles/1698893/leonardo-dicaprio-anne-hathaway-golden-globe-nominations.jhtml

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Stores Generate Business and Excitement with Flash Sales - Fox 4

KANSAS CITY, Mo. ? Still crossing names off your Christmas list? If you?re looking for a particular item, a flash sale could be your best bet to getting a deal on what you want. With only 13 shopping days until Christmas retailers are offering more flash sales than ever.

?It?s that feeling of saving money that every woman loves,? said Nikole Hudson from Amelia?s- a boutique at Briarcliff Village in Kansas City, Missouri.

She says customers are all about the bottom line nowadays.

?I definitely think the economy has changed the market, the customers definitely want a good sale I?m the same way I want to feel like I?m getting the most for my money as I possibly can,? she said.

To draw in customers ?Amelia?s like thousands of other stores across the country? is offering flash sales. A flash sale is a limited time deal on a particular item at a particular time. A flash sale can last minutes, hours or a couple days.

?Consumers love to get a deal the thrill of the hunt is part of what women love and that?s what spurs so much of our economy,? said Jeff Fromm with Barkley, a Kansas City, Missouri advertising agency. Fromm says with customers plugged in it?s easier and faster than ever for businesses to get their attention.

?You have an ever connected consumer ?in terms of their adoption of technology tools which enable retailers to connect with them and offer deals that only offer for a really short period of time,? Fromm told Fox 4.

But, not all businesses say flash sales are for them. Mary Carol Garrity owns Nell Hill at Briarcliff Village. She says not everyone wants to rush to get a deal.

?I think the customer is more savvy than they?ve ever been,? she said. ?I think we just need to make it worthwhile for them to get into the car to drive to here or Atchison.?

Garrity says quality, service and making it right is what keeps her clients coming back, ?I think some stores like the big box stores are geared toward that to sales, but we consider ourselves we?re a small business we?re a specialty store so we?re more geared to product,? she said.

Every dollar counts and this Christmas businesses nationally and locally are banking on yours.

Source: http://fox4kc.com/2012/12/12/stores-generate-business-and-excitement-with-flash-sales/

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Taking Your Online Business to the Next Level | Inspiredpen Web

Are you one of those companies with first mover advantage to the internet, but just haven?t been able to maintain success in the recent years? If your long-established business has never taken advantage of SEO services or the plethora of social media tools that exist now ? it?s unfortunate to say that more often than not, other competitors will be able to tarnish your awareness & position steadily, but strongly.

There are many aspects of internet marketing that a company can leverage. The fact that many first-mover business sites are fairly old, gives them a distinct edge over their competitors right from the get go. This is because the age of your domain name plays a part in determining your website?s credibility. The next aspect of making sure that your company has a higher level of visibility on the net is to not just focus on years of strong brand reputation that you?ve created, but instead focus on product or service related keywords to optimize your website for. Needless to say, with billion searches made every month , not everyone is searching for your brand name.

Another crucial aspect of internet marketing is social media. Many businesses are now creating communities online which allow viral marketing to take place on its own. Of course there can be negative side effects of this as well; however that is where your own business principles and ethics come into play. If there is nothing detrimental that the company does, social media marketing can be a relatively cheap and effective method to increase your company exposure on the web.

This entry was posted in Online Business and tagged Online Business. Bookmark the permalink.

Source: http://www.inspiredpenweb.com/taking-your-online-business-to-the-next-level/

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Team creates versatile 3d nanostructures using DNA 'bricks'

Friday, November 30, 2012

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have created more than 100 three-dimensional (3D) nanostructures using DNA building blocks that function like Lego? bricks ? a major advance from the two-dimensional (2D) structures the same team built a few months ago.

In effect, the advance means researchers just went from being able to build a flat wall of Legos?, to building a house. The new method, featured as a cover research article in the 30 November issue of Science, is the next step toward using DNA nanotechnologies for more sophisticated applications than ever possible before, such as "smart" medical devices that target drugs selectively to disease sites, programmable imaging probes, templates for precisely arranging inorganic materials in the manufacturing of next generation computer circuits, and more.

The nanofabrication technique, called "DNA-brick self-assembly," uses short, synthetic strands of DNA that work like interlocking Lego? bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying "recipe" of DNA base pairs: A (adenosine) only binds to T (thymine) and C (cytosine) only binds to G (guanine).

Earlier this year, the Wyss team reported in Nature how they could create a collection of 2D shapes by stacking one DNA brick (42 bases in length) upon another (http://wyss.harvard.edu/viewpressrelease/84/wyss-institute-develops-new-nanodevice-manufacturing-strategy-using-selfassembling-dna-building-blocks-).

But there's a "twist" in the new method required to build in 3D.

The trick is to start with an even smaller DNA brick (32 bases in length), which changes the orientation of every matched-up pair of bricks to a 90 degree angle?giving every two Legos? a 3D shape. In this way, the team can use these bricks to build "out" in addition to "up," and eventually form 3D structures, such as a 25-nanometer solid cube containing hundreds of bricks. The cube becomes a "master" DNA "molecular canvas"; in this case, the canvas was comprised of 1000 so-called "voxels," which correspond to eight base-pairs and measure about 2.5 nanometers in size ? meaning this is architecture at its tiniest.

The master canvas is where the modularity comes in: by simply selecting subsets of specific DNA bricks from the large cubic structure, the team built 102 3D structures with sophisticated surface features, as well as intricate interior cavities and tunnels.

"This is a simple, versatile and robust method," says Peng Yin, Ph.D., Wyss core faculty member and senior author on the study.

Another method used to build 3D structures, called DNA origami, is tougher to use to build complex shapes, Yin said, because it relies on a long "scaffold" strand of DNA that folds to interact with hundreds of shorter "staple" strands ? and each new shape requires a new scaffold routing strategy and hence new staples. In contrast, the DNA brick method does not use any scaffold strand and therefore has a modular architecture; each brick can be added or removed independently.

"We are moving at lightning speed in our ability to devise ever more powerful ways to use biocompatible DNA molecules as structural building blocks for nanotechnology, which could have great value for medicine as well as non-medical applications," says Wyss Institute Founding Director Don Ingber, M.D., Ph.D.

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Wyss Institute for Biologically Inspired Engineering at Harvard: http://wyss.harvard.edu/

Thanks to Wyss Institute for Biologically Inspired Engineering at Harvard for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/125611/Team_creates_versatile__d_nanostructures_using_DNA__bricks__

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The Packs!

Four Packs, One Land. Its Fight or Flight (Open and Accepting!)

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.

[center]I realized that I didn't put the actual name of the people in the packs, I just put the person playing them. SO! I am going to make this thread![center]
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